Foxe was born at Boston, Lincolnshire. At the age of 16 he is said to have entered Brasenose college, Oxford. His authenticated connection at the university is, however, with Magdalen college, of which he became a fellow in 1539, resigning in 1545. It was during this period of abject poverty that he was one day sitting in a church when a complete stranger handed him some money and told him not to worry as in a few days he would receive employment, which happened. He never ever found out who that stranger was.
Soon after leaving Oxford he married Agnes Randall. After holding two tutorships he was driven from England by the accession of Queen bloody Mary, and he retired to Strasbourg, where he occupied himself with a Latin history of the Christian persecutions, which he had begun at the suggestion of Lady Jane Grey.
This book, dealing chiefly with Wycliffe and Huss, and coming down to 1500, formed the first outline of the Actes and Monuments. It was printed by Wendelin Richelius with the title of Commentarii rerum in ecclesia gestarum (Strasbourg, 1554). In the same year Foxe moved to Frankfort, where he found the English colony of Protestant refugees divided into two camps, the Calvinists and the Anglicans, and made a vain attempt to frame a compromise, but failed. He moved (1555) to Basle, where he worked as a printers reader to Johann Herbst (or Oporinus). He made steady progress with his great book as he received reports from England of the religious persecutions there, and he issued from the press of Oporinus his pamphlet Ad inclytos ac praepotentes Angliae proceres . . . supplicatio (1557),a plea for toleration addressed to the English nobility. In 1559 he completed the Latin edition of his martyrology and returned to England. He lived for some time at Aldgate, London, in the house of his former pupil, Thomas Howard, now duke of Norfolk. and became associated with John Day the printer, himself once a Protestant exile. Foxe was ordained priest by Edmund Grindal, bishop of London, in 1560, and besides much literary work he occasionally preached at Pauls Cross and other places. His Martyrology had rendered great service to the Government, and he might have had high preferment in the church but for the Calvinist views which he consistently maintained, and his imperviousness to worldly ambition. He held, however, the prebend of Shipton in Salisbury cathedral, and is said to have been for a short time rector of Cripplegate.
In 1563 was issued from the press of John Day the first English edition of the Actes and Monuments of these latter and perillous Dayes . . . by John Foxe, commonly known as the Book of Martyrs. Its popularity was immense. Bloody Mary's persecution was still fresh in the people's minds, and the graphic narratives of noble suffering for the cause of Jesus Christ and His Truth, intensified in its many readers a fierce hatred for the murderous Roman Catholic Inquisition of Philip II and Spain. Nor has its influence ever waned where innocents continue to suffer for their Christian faith. There can be no doubt that for generations the conception of Roman Catholicism was derived from its pages as a dangerous despotism when it has the power to wield the secular sword through its all-too-willing collaborators.
Due to the immediate criticisms by Roman Catholic writers Foxe proceeded to produce a second corrected edition, thoroughly revised from more living witnesses of the times of persecution. It was called the Ecclesiastical History, contayning the Actes and Monuments of things passed in every kynges tyme . . . in 1570, a copy of which was ordered by Convocation to be placed in every collegiate church.
It must also be remembered in his honour that his advocacy of religious toleration was far in advance of his day. He pleaded with Elizabeth I, who respected him, to spare the lives of some despised Dutch Anabaptists, in the belief that in their ignorance they may yet come to be enlightened by the grace of God and come to see the truth. He failed in this.
He died on April 18, 1587 and was buried at St. Giles, Cripplegate.